Which of the following terms refers to the stage of cancer that indicates it is spreading beyond the original location?

The term that indicates the stage of cancer spreading beyond its original location is "metastatic." When cancer is described as metastatic, it means that cancer cells have broken away from the primary tumor and have traveled to other parts of the body through the bloodstream or lymphatic system, forming secondary tumors. This stage is crucial in cancer classification as it often affects treatment options and prognosis.

In contrast, the term "localized" refers to cancer that is confined to its original site without any evidence of spread. "Advanced" typically indicates a later stage of cancer that may involve regional spread, but it is not as specific as "metastatic," which clearly denotes the presence of distant spread. "Remission" signifies a period during which the signs and symptoms of cancer decrease or disappear, but it does not indicate whether the cancer has spread. Therefore, "metastatic" is the most precise term to describe cancer that has spread beyond the original site.